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Methods 246 WangS.ParthasarathyS.NishiyamaY.EndoY.NemotoT.YamauchiK.et al (2015a)

Treatments are quick, making them easy to maintain on a weekly or monthly basis

It is typically thought to be well tolerated in animal research

Phase 2 of rehabilitation consists of days 3-14 after the procedure

While our in vitro developability assessments were performed on a small cohort of target-specific, high-expression antibodies from each repertoire and requires validation in a larger, more unbiased subset to definitively attribute native pairing to gains in developability, the bioinformatic workflows employedparticularly our clustering-based clonal selection strategiessuggest that the selected antibodies should be representative in sequence and function of the larger target-specific diversity