Two randomized controlled trials published in JAMA Network Open by Imperial College London (2022 and 2023) found that kisspeptin significantly changed brain activity in key sexual processing regions in both women and men with low libido, with no reported adverse effects in either study
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MM: Writing review & editing, Investigation, Formal analysis
Four reasons GLP-1s affect sleep Circadian rhythm disruption GLP-1 receptors in the hypothalamus modulate GABA, orexin, and melatonin, shifting sleep-wake cycles Blood sugar fluctuations Your body adjusts to new overnight glucose patterns, disrupting sleep cycles during adaptation Physical side effects Night sweats, digestive discomfort, and nausea peak during the first 46 weeks and dose escalation periods Psychological factors Adjusting to a new relationship with food and body image can trigger anxiety or racing thoughts at night Free Resource Get Dr