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Notably, tirzepatide is characterised in the literature as an imbalanced or biased dual agonist: its affinity for the GIP receptor is comparable to native GIP, while its affinity for the GLP-1 receptor is roughly 18- to 20-fold weaker than native GLP-1

Missing doses during titration slows the entire process and may require restarting at a lower dose

Key factors to consider when timing your GLP-1 doses Ultimately, the best time for your GLP-1 injection is what works for your body and your lifestyle

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Other medications may stay in your stomach longer and their affect could be delayed