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Tirzepatide (Mounjaro) injection
Thanks for this great review showing the need to move the paradigm away from just small solute clearance as a measure of PD prescribing
Some are approved by the US Food and Drug Administration (FDA) just for weight loss, along with healthy lifestyle changes, including a reduced-calorie diet and increased physical activity
Specifically, teplizumab is an anti-CD3 antibody that interferes in the autoimmune destruction of pancreatic beta cells to help delay type 1 diabetes
Correspondingly, the treatment of GLP-1 RAs for one week in rats with type 2 diabetes could reduce NOX3 and SOD2 levels in the retina cells, alleviate autophagy through the GLP-1R-ERK1/2-HDAC6 signaling pathway, and finally improve DR [34]
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