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Blocking GSH synthesis in combination with JMF4073 depletes dTTP/dCTP pools to eradicate T315I-Bcr-Abl leukemia We hypothesize that reducing the GSH level to increase replication stress can render T315I-Bcr-Abl leukemia more susceptible to JMF4073 in vivo

It also causes nausea, headache, and allergy-like histamine release

Nausea or Upset Stomach: In rare cases, individuals may experience mild nausea or upset stomach