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When intended only to cover and protect a wound, to absorb exudate, and to maintain appropriate moisture balance within the wound and otherwise meeting the device definition, generally the FDA's Center for Devices and Radiological Health (CDRH) regulates wound dressings composed of natural biomaterials, including animal and human derived tissue as devices, and they are currently subject to 510(k) requirements

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It is also described in mechanistic contexts involving nitric oxiderelated pathways, growth factor expression, and cellular processes tied to migration and adhesionconcepts often studied when researchers are investigating how tissues respond and reorganize after experimental injury or stress