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Rarer neurologic manifestations can include seizures (12)

Photograph affected areas in consistent lighting

However, since then, the field has continued to progress rapidly, with recent animal studies and early-phase clinical trials that highlight the efficacy and feasibility of IN delivery for iron chelators ( 2 Impaired iron homeostasis and brain dysfunction Iron is essential for multiple biological functions, including oxygen transport, redox actions, and DNA synthesis (Khn, 2015)