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Exposure of cultured human hepatocytes to alcohol increased the expression of CYP-2E1 and CYP-3A3/4 up to 6-fold, but the effect appeared to be individually variable[47]

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You can however see results with this metabolic game changer

Drug molecules and activated form of glucuronic acid are present in the cytosol while UGT is present in SER so drug molecules and UDPGA are transferred to SER where glucuronic acid conjugation occurs and metabolite/conjugated product is transferred to the cytoplasm [10]