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This review provides a comprehensive overview of the latest treatment options for the entire PKU patient population including (i) dietary restriction of Phe supplemented with other amino acids and micronutrients through medical formulas, (ii) daily administration of large neutral amino acids, (iii) a synthetic form of BH4 and (iv) bacterial phenylalanine ammonia lyase enzymes

Fatigue, which can be compounded by both the medication and the menstrual cycle

Advances in modern technologies have enabled -cells to be considered not as a uniform population but as a highly organized and functionally diverse system

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