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But once a few compounds in a category prove clinically useful, it becomes very easy for the rest of the category to borrow that credibility, even when the evidence lags significantly behind

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PMID: 38462207 Mol CarcinogLoss of PTPRS elicits potent metastatic capability and resistance to temozolomide in glioblastoma

Its proposed mechanisms involve multiple cytoprotective pathways including upregulation of VEGF and growth factors promoting angiogenesis, modulation of the nitric oxide system, activation of the FAK-paxillin pathway for cell migration and tissue repair, interaction with the gut-brain axis affecting dopaminergic and serotonergic systems, and gastroprotective effects against NSAID and alcohol-induced mucosal damage

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