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Analysis of oxidative stress levels in the prefrontal cortex ELISA analysis revealed that valproic acid (VPA) exposure significantly disrupted oxidative stress homeostasis in the prefrontal cortex of SD rats

Nat Cell Biol 2015

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Memory (escape latency in the Morris water maze test), neurotransmitters (acetylcholine, dopamine, gamma-amino butyric acid (GABA)), and neurochemicals (BDNF, catalase, glutathione, Amyloid Beta and cyclic GMP) were analyzed from whole brain samples in young (8-weeks-old) and aged (16-months-old) rats following 12 days of supplementation (100 mg/d HED of 1-MX [UPLEVEL, Ingenious Ingredients L.P., Lewisville, TX, USA]) via oral gavage