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Wegovy (semaglutide) How it works: Like Saxenda, Wegovy is a GLP-1 analogue - but with once-weekly injections and stronger appetite suppression

Peripheral tissues like skin (high turnover rates, moderate mitochondrial capacity) are particularly vulnerable

For GLP-1 RA therapy, this implies that weight loss in this population likely derives primarily from appetite suppression rather than from correcting pre-existing metabolic abnormalities, informing expectations about therapeutic mechanisms and outcomes

JA1 and JA8 stimulated a release of 3155 276 pM and 2518 141 pM GLP-1, respectively (Fig

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