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These results demonstrate a clear effect of BCATi to inhibit BCATm in the muscle, where it is known to be highly expressed, with little effect in liver, which has very low levels of expression of the enzyme

Cell culture Rat pheochromocytoma cells (PC12) were obtained from the American Type Culture Collection (Manassas, VA, USA), and were cultured in Dulbeccos Modified Eagles medium supplemented with 6% fetal bovine serum (heat inactivated), 6% horse serum (heat inactivated), 1 mm glutamine, 100U ml 1 penicillin and 100 g ml 1 streptomycin at 37 C in a humidified 5% CO 2 incubator

Sofroniew, 2009), which are closely related to glial scar formation

It is safe for long-term use when taken within recommended dosage guidelines

Bakewell, Melanie Narkunan, Amy Le, Varsha Karanam, Kang Li, Aum Mhapankar, Luke Norton, Jean Ross, M