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One specific consideration for tirzepatide users: because the once-at-room-temperature-can't-return-to-fridge rule means the 21-day clock runs from first removal from refrigeration, consider timing your pen removal carefully around your trip

A Study of Tirzepatide (LY3298176) in Participants With Type 2 Diabetes on Metformin With or Without Sulfonylurea (SURPASS-AP-Combo)

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TABLE 1 Direct impact of sulfonylureas and indirect modulation of sulfonylureas targeting Epac on ion channels besides K ATP channels