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This medication stimulates appetite through changes in hypothalamic signaling and increases cortisol levels, which promote fat storage around the midsection and elevate blood sugar

doi:10.1016/s2213-8587(17)30092-x 5.Nauck MA, DAlessio DA

Butyrate is the primary energy source for colonocytes and acts as a signaling molecule (G protein-coupled signaling receptors (gpcrs), activating GPR41 and GPR43, which are protein-coupled receptors [117]

The dosage and duration of therapy should be individualized by the physician according to the patients response and underlying cause of deficiency