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Vitamin B3 helps to modulate anabolic reactions such as synthesis of cholesterol and fatty acids

The swish step recovers some of the compound that mixed with saliva during the hold period

and bioorthogonal conjugation of immunomodulators to the EcN surface, where dissolution of an enteric coating in the intestine exposes the conjugates to drive macrophage polarization from pro-inflammatory M1 to anti-inflammatory M2, complementing the probiotic's intrinsic effects (Peng et al., 2024)

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