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The phase 3 REDEFINE 1 trial expanded on these findings dramatically

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Reconstitution & Handling Guidelines Because of the highly concentrated peptide mass (80mg) and the inclusion of the copper ion complex, reconstitution must be handled methodically to avoid shearing the peptide bonds: Recommended Solvent: Bacteriostatic Reconstitution Solution (0.9% Benzyl Alcohol)

286 These findings support ongoing investigations of eplontersen in ATTR-CM (NCT04136171), with a focus on its potential to improve cardiac structure and function