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compared the levels of proinflammatory cytokines in tears between GD patients and healthy controls and discovered that the release of IL-1, IL-6, IL-13, IL-17A, IL-18, TNF-, and RANTES significantly increased in patients with GD and Graves ophthalmopathy (GO) (34)

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IGF-1 DES has 20-30 minute half-life, minimal IGFBP binding, highest receptor affinity and potency, localized effects at injection site, and requires frequent dosing for sustained effects

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