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therefore, bleeding risk depends not only on INR but also on patient-specific and lesion-specific factors it is necessary to distinguish between major and minor bleeding major bleeding includes fatal bleeding, bleeding in a critical site, a hemoglobin decrease of 2 g/dL, or transfusion of 2 units of red cells critical-site bleeding: intracranial, intraspinal, intraocular, pericardial, retroperitoneal, or intramuscular bleeding with compartment syndrome mild/minor bleeding encompasses epistaxis, skin hematomas, suffusions, and micro/macroscopic hematuria

Food and Drug Administration (FDA) to help control blood sugar and treat type 2 diabetes, semaglutide (brand names Ozempic, Wegovy and Rybelsus) has also emerged as a popular obesity and weight loss treatment