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Results were considered statistically significant at p 80%) and concerns regarding imprecision and risk of bias were the main factors contributing to downgrading (Supplementary Table S3)

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pylori infection chronic excess alcohol use pancreatic insufficiency intestinal bacterial overgrowth Gastrectomy/ bariatric surgery and gastritis Causes of food cobalamin malabsorption can be directly related with the stomach: Bariatric surgery it can depend on the type of procedure and what area of the stomach or intestines are removed Gastrectomy removal of part or all of the stomach Gastritis inflammation of the stomach lining Gastrectomy, bariatric surgery, and gastritis cause vitamin B12 deficiency due to an absence of stomach acids that help to remove vitamin B12 from food proteins, for example red meat