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It is thought to benefit the entire gastrointestinal tract, as well as playing a positive role following strokes, schizophrenia, and spinal cord injuries [9]

Dynamic expression of de novo DNA methyltransferases Dnmt3a and Dnmt3b in the central nervous system

This is particularly important for individuals with conditions that interfere with B12 absorption, such as pernicious anemia, gastrointestinal disorders like celiac disease or Crohns disease, or those who have undergone certain types of gastrointestinal surgery

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This NADPH is likely supplied by the activity of Ald6 an aldehyde dehydrogenase which has previously been shown to be critical in the absence of a functional pentose phosphate pathway (Grabowska and Chelstowska, 2003)