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To view a copy of this licence, visit About this article Cite this article Roider, E., Lakatos, A.I.T., McConnell, A.M

In hypoxic conditions, HIF-1 acts as the main mediator of a series of in vivo pathophysiological responses, including angiogenesis, cell proliferation, and transcriptional induction of survival genes ( Erythropoietin (EPO) is the first protein that has been identified downstream of HIF-1 to activate erythropoiesis ( Shh signaling pathway The sonic hedgehog (Shh) signaling pathway plays an important role in endogenous neurogenesis (40)

The mechanisms of action of CoQ10 include restoring ROS imbalances and preventing DNA damage and oocyte apoptosis (Zhang et al., 2019)

Glutamine-driven oxidative phosphorylation is a major ATP source in transformed mammalian cells in both normoxia and hypoxia

Nkya TE, Akhouayri I, Kisinza W, David JP