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Whether the same magnitude of risk reduction occurs in a population with inherited cardioprotection remains unknown, as the low baseline risk may attenuate absolute benefits - a phenomenon known as a ceiling effect

In some cases, switching to a different medication with a different pharmacokinetic profile may be appropriate, as individual responses vary

This typically happens when people use 1.0 mL of water (5.0 mg/mL) for low doses like 0.25mg

In 2021, the FDA approved a third semaglutide formulation, Wegovy, for chronic weight management for those with obesity or overweight and at least one weight-related condition

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