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These venomous lizards, native to the southwestern United States and northwestern Mexico, are renowned as one of the few medically significant venomous lizards globally, alongside the Mexican beaded lizard ( Heloderma horridum )
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Nevertheless, the insulin resistance and abdominal adiposity seems to be essential in the pathophysiological process, and for this reason, based on the information available, we propose IGF-1 as a key hormone in the pathophysiology of metabolic syndrome due to its implications in the metabolism of carbohydrates and lipids
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