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Although gout can be considered an acute consequence of periods of hyperuricemia and is easily recognizable by the associated severe joint pain, particularly in the large toe joints, there are many metabolic disturbances that result from chronic hyperuricemia that are far more problematic from the perspective of morbidity and mortality

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Extreme high-temperature conditions can increase body temperature and adversely impact mammalian biological functions, leading to impaired production and reproductive traits 38,39

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