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In the case of GSTs, these multifunctional and essential enzymes are involved in many processes, such as detoxification, signaling, redox homeostasis, plant metabolism, growth regulation, and adaptation to biotic and abiotic stress (Sabetta et al., 2017)

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Familial aggregation of autoimmune diseases is commonly observed, with ankylosing spondylitis exhibiting particularly high rates of prevalence among first-degree relatives, reaching up to 1030% compared with the general population [25]

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