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Referral to endocrinology, urology, gynecology, or sexual medicine specialists may be appropriate for complex cases requiring specialized evaluation and management

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More than three decades ago, Maher, Schubert and colleagues delineated a non-excitotoxic, regulated cell death pathway triggered by glutamate, later termed oxytosis , which is characterized by GSH depletion, ROS accumulation, and calcium influx (Tan et al., 2001)