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Evolving Considerations in Obesity Clinical Trials: Weight Plateau, Excessive Weight Loss, and Dose Flexibility as a Possible Strategy These two articles have been of particular interest to me from two perspectives related to clinical trials: 1

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Quantification of the plateau (middle) and the rate of ligand-induced conformational change (right) for each agonist (1 M GLP-1 and 10 M TT-OAD2) was calculated by applying a one-phase association curve to the kinetic data with values from each individual experiment show in black circles

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For some patients, that means delaying surgery for 2-3 months while we get their nutrition optimized