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These include: Nausea (very common, affecting up to 20% of patients) Diarrhoea (very common) Vomiting (common) Abdominal pain (common) Constipation (common) Dyspepsia (common) These gastrointestinal effects typically emerge during treatment initiation or dose escalation and often diminish over time as the body adapts to the medication

Many of the older studies used outdated methodologies that would not be considered high quality by todays standards