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This review synthesizes current evidence on the bidirectional associations between periodontitis and a broad spectrum of systemic disorders, including cardiovascular disease (CVD), diabetes mellitus (DM), respiratory diseases, preterm birth, Alzheimers disease (AD), chronic kidney disease (CKD), rheumatoid arthritis (RA), and Helicobacter pylori ( H

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Eisai has done a bit better with Belviq, but its no blockbuster yet