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DISCUSSION The 2023 assessment that GLP-1 agonist drugs were the scientific of breakthrough of the year was prescient

Multiple investigational therapies ranging from tolerogenic to immunological approaches are in the pipeline, and several drug candidates have entered phase II/III clinical trials

The anti-glycation effect of DEC-containing serum on pigmented full-thickness human skin model Exposure of the skin model to MGO and UV irradiation induced a marked upregulation of CML, a well-characterized biomarker for AGEs formation 18

While many patients experience significant improvement, the treatment process requires patience