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National Institutes of Health [NIH], National Institute of Diabetes and Digestive and Kidney Diseases, Bethesda, MD, 2022

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It is reported that high concentrations of fumarate and succinate can enhance the 3-methylation of histones H3K4 and H3K27 by inhibiting KDM5 histone demethylase (responsible for H3K4 demethylation) and JMJD3 histone demethylase, respectively, which in turn promotes the expression of pro-inflammatory cytokine genes (125, 161, 162)

doi: 10.1590/0001-3765201520140671 183 Molnar-KaszaA.HintereggerB.NeddensJ.RablR.FlunkertS.Hutter-PaierB