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Piperine co-administration inhibits phase II glucuronidation and sulphation via competitive enzyme inhibition, thereby augmenting systemic curcumin exposure by an estimated 2- to 20-fold in human pharmacokinetic studies, although the magnitude of enhancement varies with dose and timing (Figure 1)

L., Moloney, R

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This brings up a potential drawback to the use of GLP-1 analogs in IBD, since patients may already be experiencing diarrhea or other symptoms in their digestive tract due to their disease

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