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25 The body's antioxidant defenses weaken with age, reducing their capacity to counteract ROS

Niacinamide may support cellular energy metabolism during the metabolic changes GLP-1 therapy induces

Control of mitochondrial and -cell function by SPHKAP-dependent GLP-1R signalling We next assessed the effect of ERMCS-localised GLP-1R-induced PKA signalling in the control of mitochondrial function in INS-1 832/3 cells

However, their clinical application requires rigorous evaluation of therapeutic efficacy, comprehensive safety profiling, and well-defined patient selection criteria