G6PD produces nicotinamide adenine dinucleotide phosphate (NADPH) for red blood cell protection from oxidative stress
The study on the brains of the Mecp2-308 mouse model of ASD has shown a reduced ATP production accompanied by a significant reduction in complexes I, II, and V activities in the cerebellum and striatum of the mutant mice [78]
[116], the increased production of superoxide radicals (O 2 ) resulting from T2D hyperglycemia can rapidly react with nitric oxide (NO) to produce peroxynitrite (ONOO ), which can subsequently react with protein (and apolipoprotein) tyrosine residues to form 3-nitro-tyrosine (3-NT)
The incidence is relatively low, affecting less than five percent of patients with pre-existing retinopathy, but regular ophthalmologic monitoring is recommended for patients with diabetes-related eye disease
Can J Physiol Pharmacol 97(1):3746 Hasanvand A, Hosseinzadeh A, Saeedavi M et al (2022) Neuroprotective effects of tannic acid against kainic acid-induced seizures in mice [J]
