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It is also noteworthy that the study was funded by the International Treatment Preparedness Coalition (ITPC), and one of the authors disclosed receiving lecture honoraria and research grants from pharmaceutical companies

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Also, metabolites of VPA -oxidation (including propionic derivatives and 4-en-VPA) inhibit the mitochondrial CPS I, which is the first enzyme necessary for ammonia elimination via the urea cycle in the liver [19, 24]

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In contrast, nitric oxide is decreased by imipramine

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