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Context-dependent functional differences among AREs fit with findings from another group that combined high-throughput promoter-dependent drug screens and transcriptomics analyses to uncover that low doses of the chemotherapeutic doxorubicin downregulate cell cycle genes while high doses upregulate DNA damage response genes

Notably, this reduction in systemic LPS was accompanied by a down-regulation of pro-inflammatory mediators (e.g., TLR4, NF-B, and IL-6) in the uterus, suggesting that butyrate can alleviate high-grain induced inflammation across the gut-uterus axis by fortifying the epithelial barrier 166

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GSSG cannot be used to bind xenobiotics, it first must be converted back to GSH

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