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There are no major contraindications identified with GHK-Cu, and it is considered safe for extended use

In an injectable context, applying that same logic, a visibly degraded solution is a different and more serious concern, since you'd be introducing degradation products and potentially free copper ions rather than the intended complex

The genetic or pharmacological restoration of GPX4 suppresses neutrophil ferroptosis and abrogates downstream autoimmunity, underscoring GPX4 as a checkpoint that constrains iron-driven inflammation (206, 217)

When kept in the fridge and reconstituted with BAC water, your GHK-Cu solution will remain stable and potent for at least 4-6 weeks