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In particular, TMAO was shown to trigger platelet activation and thrombosis via increasing the platelet responsiveness by enhancing stimulus (ADP, collagen, thrombin, or arachidonic acid)-dependent mobilization of intracellular Ca 2+ stores in platelets (Zhu et al., 2016

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We will continue to review our benchmarking approach as the model evolves to ensure it effectively rewards high-quality care delivery and promotes continuous improvement while maintaining fair and meaningful performance standards

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