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Rats were assessed for fine motoric impairment with modified Irvine, Beatties and Bresnahan forelimb scale (IBB scale) that can detect recovery of both proximal and distal forelimb function including digit movements during a naturally occurring behavior that does not require extensive training or deprivation to enhance motivation (64)

Reported preclinical effects on sleep architecture and stress endpoints are not of a magnitude that would predict robust clinical signal even if a clean delivery system were available

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