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1 Department of Diabetes Research, APDP - Diabetes Portugal, Lisbon, Portugal, 2 Department of Clinical Sciences, Lund University, Malm, Sweden, 3 Department of Paediatrics, 2nd Faculty of Medicine, Charles University and University Hospital Motol, Prague, Czechia, 4 Institute of Diabetes Research, Helmholtz Munich, German Research Center for Environmental Health, Neuherberg, Germany, 5 Internal Medicine, San Raffaele Scientific Institute, Milan, Italy, 6 Center for Regenerative Therapies Dresden, Technical University Dresden, Dresden, Germany, 7 Department of Translational Type 1 Diabetes Research, Clinical and Translational Research, Steno Diabetes Center, Copenhagen, Denmark, 8 Institute of Immunology and Immunotherapy, University of Birmingham, Birmingham, UK, 9 Department of Paediatric Diabetology and Paedriatics, Medical University of Warsaw, Warsaw, Poland, 10 Department of Chronic Diseases and Metabolism, KULeuven, Leuven, Belgium, 11 Endocrinology, UZ Leuven, Leuven, Belgium

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In contrast, antihypertensive treatment with hydralazine significantly lowered blood pressure but failed to normalize vascular superoxide formation, despite increasing sGC expression

High sodium intake can lead to increased fluid retention

The prevention of the glucagon rise might improve the beneficial effects of the combination therapy to enhance glucose control and may support this combination therapy in clinical practice [81]