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doi: 10.1053/j.gastro.2005.09.001 155 DeFronzoRABuseJBKimTBurnsCSkareSBaronAet al

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No lethal dose identified at doses up to 20 mg/kg in animal studies No organ toxicity observed across multiple organ systems Negative mutagenicity testing across standard assays No teratogenic effects in pregnancy studies Limited long-term human data beyond 6 weeks Theoretical Considerations The primary theoretical concern relates to BPC-157s angiogenic properties