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Endocrinology 1994;134:2156-64.ArticlePubMed 10

F.SoletiA.PaoliniM.et al (2009)

While GLP-1 degradation is unaffected by kidney function, the clearance of both GLP-1, and to a greater extent its inactive metabolites, is delayed in patients with renal insufficiency [184]

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Experimental data point oxidative stress as one of the factors that contributes to aquaporin-1 up-regulation since administration of the antioxidant melatonin not only reduced protein levels but also mechanical allodynia and appearance of aquaporin-1-positive fibers below laminae I and II (Nesic et al., 2008)