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For patients with metabolic syndrome, GH-axis deficiency, and visceral obesity who have not found sufficient relief through diet, exercise, or even GLP-1 therapy tesamorelin represents a mechanistically distinct and clinically validated option
Moreover, the Erysipelotrichaceae family is primarily responsible for the production of acetate and butyrate, based on metatranscriptome profiles ( Coriobacteriaceae family positively correlates with the serum LDL-C levels in mice fed with a high fat diet (HFD) ( BAs mainly exist as primary BAs, chenodeoxycholic acid (CDCA), and cholic acid (CA) before fermentation by gut microbiota, whereas the SBAs, deoxycholic acid (DCA), and lithocholic acid (LCA) are generated by Clostridium and some strains of Lachnospiraceae and Peptostreptococcaceae families in the gut
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doi: 10.1186/s13045-020-00904-3 43 NitulescuGMVan De VenterMNitulescuGUngurianuAJuzenasPPengQet al
