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Additionally, mitochondrial energy metabolism and inflammatory cytokines pathways were unaffected or downregulated, and no changes in functional readouts like hand grip strength were observed

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Additionally, we analyzed postmortem human brain tissue with histopathologically confirmed AD or progressive supranuclear palsy (PSP), an age-associated tauopathy that clinically manifests as parkinsonism with additional motor abnormalities and cognitive dysfunction, and is neuropathologically defined by NFTs, gliosis and neurodegeneration (104)