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TBC1D9B was particularly interesting because of its putative function as a GTPase-activating protein (GAP) and its hypothesized role in endo-lysosomal trafficking, possibly by modulating the function of RAB proteins (i.e., RAB11A) 38 and/or related small GTPases

The two rostral burr holes were placed just basal from the posterior interocular line, the two basal burr holes were placed just rostral to the lambdoid suture (and transverse sinuses) on both sides, respectively, and the middle two burr holes were placed in the line between the basal and rostral burr holes

28 In hepatocytes, SIRT1 increases insulin sensitivity by activating the LKB1/AMPK pathway, improving cellular responsiveness to insulin

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The findings of an RCT showed that combining pharmacological agents effectively reduced postoperative inflammatory factor expression (IL-1, IL-6, and TNF-) compared with transforaminal endoscopic spinal surgery alone [23]