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10.1111/imm.12231 63 MelchersK.HerrmannL.MauchF.BayleD.HeuermannD.WeitzeneggerT.et al (1998)

When the influx of environmental toxins exceeds the body's ability to clear them, or when chronic illness depletes the specific nutrients required for these pathways, heavy metals begin to accumulate in tissues, particularly in the liver, kidneys, and central nervous system

If your gut isnt absorbing it properly, much of it simply doesnt make it into your bloodstream

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Intakes of vitamins A, C, and E and use of multiple vitamin supplements and risk of colon cancer: a pooled analysis of prospective cohort studies