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3.4 Effects of aging and sleep on the glymphatic system and neuron-glial redox coupling in brain health Aging also impairs the glymphatic system, a crucial brain-wide clearance network responsible for removing interstitial waste products, including neurotoxic and ROS-generating protein aggregates such as amyloid-, -synuclein, and neurofibrillary tangles (Rasmussen et al., 2018

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10.1074/jbc.M601203200 J

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