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Leibel RL, Rosenbaum M, Hirsch J

Rescue of defective insulin secretion has been achieved by two pharmacological paradigms: high agonist concentrations or a combination of low agonist concentration and positive allosteric modulators (PAMs) for some mutants

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However, their therapeutic outcomes are limited because of drug resistance due to the intracellular inactivation effect ( 2 complex with platinum drugs