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Novel triple-G agonists Retatrutide is a novel, once-weekly injectable agent that acts on GIP, GLP-1 and glucagon receptors, and has shown promise in clinical trials for significant weight loss

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In September 2025, an investigation published by the BMJ revealed that patients were being pushed towards the black market to purchase weight-loss drugs, which it suggested may be because of poor access to drugs on the NHS and the Mounjaro price hike

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